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Conducting scaffolds for liver tissue engineering
Author(s) -
Tahmasbi Rad Armin,
Ali Naushad,
Kotturi Hari Shankar R.,
Yazdimamaghani Mostafa,
Smay Jim,
Vashaee Daryoosh,
Tayebi Lobat
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35080
Subject(s) - materials science , tissue engineering , liver tissue , biomedical engineering , mechanical engineering , systems engineering , nanotechnology , engineering , medicine
It is known that there is a correlation between a cell membrane potential and the proliferation of the cell. The high proliferation capacity of liver cells can also be attributed to its specific cell membrane potential as liver cell is recognized as one of the most depolarized of all differentiated cells. We hypothesized that this phenomenon can be emphasized by growing liver cells in conducting scaffolds that can increase the electrical communication among the cells. In this article, using tissue engineering techniques, we grew hepatocyte cells in scaffolds with various compositions. It was found that the scaffolds containing conducting polymer of poly (3,4‐ethylenedioxythiophene) (PEDOT) provide the best condition for attachment and proliferation of the cells. More specifically, the blend of hyaluronan, PEDOT, and collagen (I) as dopants in gelatin–chitosan‐based scaffold presented the best cell/scaffold interactions for regeneration of liver cells. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 4169–4181, 2014.