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Enhanced osseointegration and antibacterial action of zinc‐loaded titania‐nanotube‐coated titanium substrates: In vitro and in vivo studies
Author(s) -
Li Yong,
Xiong Wei,
Zhang Chengcheng,
Gao Biao,
Guan Hanfeng,
Cheng Hao,
Fu Jijiang,
Li Feng
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35060
Subject(s) - osseointegration , materials science , in vivo , zinc , titanium , anodizing , biomedical engineering , nanotechnology , in vitro , nanotube , chemical engineering , implant , composite material , metallurgy , biochemistry , chemistry , aluminium , carbon nanotube , medicine , surgery , biology , microbiology and biotechnology , engineering
Poor osseointegration and infection resulting from implants are serious medical issues, and it is not straightforward to manufacture implants that can simultaneously address both of these problems. In this study, we produced coatings containing titania nanotubes (TiO 2 ‐NTs) incorporated with zinc (NT‐Zn) on Ti substrates by anodization and hydrothermal treatment. The zinc content was controlled by varying the duration of the hydrothermal treatment. The NT‐Zn implants not only exhibited improved bone formation (shown by both in vitro and in vivo studies), which enhances osseointegration between bone and implant, but also inhibited growth of bacteria. The cytotoxicity of locally high concentrations of zinc in the NT‐Zn3h specimens observed during in vitro studies was mitigated by the effects of dilution in vivo . © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3939–3950, 2014.