Premium
Simultaneous immobilization of heparin and gentamicin on polypropylene textiles: A dual therapeutic activity
Author(s) -
Degoutin Stéphanie,
Jimenez Maude,
Chai Feng,
Pinalie Thibaut,
Bellayer Severine,
Vandenbossche Marianne,
Neut Christel,
Blanchemain Nicolas,
Martel Bernard
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35059
Subject(s) - gentamicin , materials science , heparin , antimicrobial , polypropylene , biomedical engineering , antibiotics , composite material , chemistry , organic chemistry , biochemistry , medicine
Abstract The aim of this work was to prepare a nonwoven polypropylene (PP) textile functionalized with bioactive molecules in order to improve simultaneously anticoagulation and antibacterial properties. The immobilization of either heparin (anticoagulation agent) or gentamicin (aminoglycoside class antibiotic) alone has already been proven to be effective on PP nonwoven textiles. In this work, we managed to go further, by immobilizing both heparin and gentamicin at the same time on one unique textile. A successive immersion in different heparin and gentamicin bathes successfully led to a dual drug coated textile, as confirmed by several characterization techniques (Fourier transform infrared–attenuated total reflectance, X‐ray photoelectron spectroscopy, and scanning electron microscopy). The immobilization times were varied in order to determine the best compromise between cytocompatibility, anticoagulant effect, and antimicrobial activity. Short immersion times in gentamicin solutions confer very good antimicrobial activity to the textile and avoid cytotoxicity, whereas long immersion times in heparin solution were necessary to observe a significant anticoagulant effect. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3846–3854, 2014.