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Layer‐by‐layer assembly of silica nanoparticles on 3D fibrous scaffolds: Enhancement of osteoblast cell adhesion, proliferation, and differentiation
Author(s) -
Tang Yanwei,
Zhao Yan,
Wang Xungai,
Lin Tong
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35050
Subject(s) - materials science , osteoblast , adhesion , layer (electronics) , cell adhesion , nanoparticle , layer by layer , cell growth , nanotechnology , composite material , in vitro , biochemistry , chemistry , biology , genetics
Abstract Silica nanoparticles were applied onto the fiber surface of an interbonded three‐dimensional polycaprolactone fibrous tissue scaffold by an electrostatic layer‐by‐layer self‐assembly technique. The nanoparticle layer was found to improve the fiber wettability and surface roughness. Osteoblast cells were cultured on the fibrous scaffolds to evaluate the biological compatibility. The silica nanoparticle coated scaffold showed enhanced cell attachment, proliferation, and alkaline phosphatase activities. The overall results suggested that interbonded fibrous scaffold with silica nanoparticulate coating could be a promising scaffolding candidate for various applications in bone repair and regeneration. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3803–3812, 2014.