Premium
Endothelialization of implanted cardiovascular biomaterial surfaces: The development from in vitro to in vivo
Author(s) -
Liu Tao,
Liu Shihui,
Zhang Kun,
Chen Junying,
Huang Nan
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35025
Subject(s) - in vivo , biocompatibility , biomedical engineering , biomaterial , materials science , progenitor cell , surface modification , restenosis , endothelium , in vitro , endothelial progenitor cell , nanotechnology , medicine , microbiology and biotechnology , stem cell , chemistry , surgery , biology , stent , biochemistry , metallurgy
Restenosis and thrombosis formation after cardiovascular devices implantation continue to be problematic. Although various platforms and parameters of cardiovascular devices have been designed and optimized over the years, postoperative complications are hard to avoid. The native vascular endothelium always provide a nonthrombogenic surface as well as prevent intimal overproliferation, thereby, the presence of a confluent endothelial cell layer on material surfaces have been widely accepted as an ideal approach to improve the biocompatibility of implanted cardiovascular materials. Endothelialization on biomaterial surfaces is initially developed by in vitro cell seeding. However, numerous no‐perfect parts of this method are existed for clinical use. The emergency of endothelial progenitor cells may provide a promising way for setting these limitations. Over the last decades, countless researches about EPCs‐based in vivo induced self‐endothelialization have been reported and mainly focused on cellular therapy, pharmacological therapy, materials designing, or surface biofunctional modification. This review details the development of endothelialization on cardiovascular material surfaces from in vitro to in vivo . Endothelialization progress on the basis of molecular biological level and bioinformatics theory is expected to be the key point in the coming decades. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3754–3772, 2014.