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Molybdenum effect on the structure of SiO 2 –CaO–P 2 O 5 bioactive xerogels and on their interface processes with simulated biofluids
Author(s) -
Ponta Oana,
CiceoLucacel Raluca,
Vulpoi Adriana,
Radu Teodora,
Simon Simion
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34989
Subject(s) - biocompatibility , materials science , x ray photoelectron spectroscopy , fourier transform infrared spectroscopy , scanning electron microscope , thermogravimetric analysis , simulated body fluid , molybdenum , chemical engineering , biomaterial , nuclear chemistry , apatite , nanotechnology , composite material , metallurgy , chemistry , engineering
The study is focused on synthesis, investigation of the structural and morphological changes induced by MoO 3 addition, and thermal treatment, as well as in vitro characterization of a new sol–gel derived SiO 2 –CaO–P 2 O 5 bioactive materials. The obtained systems are composite materials consisting of nanocrystalline apatite, bioactive glass and CaMoO 4 nanoparticles, which are of interest for both regenerative medicine and specific medical applications of the releasable molybdenum ions. The changes induced by the thermal treatments and MoO 3 addition with respect to the structure and morphology were completed using differential thermal analysis\thermogravimetric analysis, X‐ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X‐ray (EDX), X‐ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) spectroscopy, electron paramagnetic resonance, and Brunauer–Emmett–Teller. The biological performance of these materials was evaluated in vitro by performing bioactivity and biocompatibility tests. The bioactive properties in terms of hydroxyapatite layer formation on the biomaterial surface after simulated body fluid immersion were studied by XRD and SEM. To establish their biocompatibility, the biomaterials surface was functionalized with protein and the resulted sample was investigated using SEM, FTIR, and XPS. The obtained results suggest that the addition of molybdenum oxide in proper concentration improves the biocompatibility in terms of enhancement of protein adherence on Si – Ca – P surface due to CaMoO 4 crystalline phase development and does not inhibit bioactivity. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3177–3185, 2014.