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Enhanced osteoconductivity of titanium implant by polarization‐induced surface charges
Author(s) -
Nozaki Kosuke,
Wang Wei,
Horiuchi Naohiro,
Nakamura Miho,
Takakuda Kazuo,
Yamashita Kimihiro,
Nagai Akiko
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34980
Subject(s) - materials science , titanium , implant , polarization (electrochemistry) , biomedical engineering , osseointegration , surgery , medicine , chemistry , metallurgy
This study introduces the application of method for electrically polarizing titanium implants coated with anatase TiO 2 using microarc oxidation. It also describes the features of the electrically polarized titanium implants, on which surface charges are generated by the dipole moment of the TiO 2 , and describes how the surface charges affect the implants' in vivo bone–implant integration capability. A comprehensive assessment using biomechanical, histomorphological, and radiographic analyses in a rabbit model was performed on polarized and nonpolarized implants. The electrically polarized surfaces accelerated the establishment of implant biomechanical fixation, compared with the nonpolarized surfaces. The percentage of the bone–implant contact ratio was higher using polarized implants than using nonpolarized implants. In contrast, the bone volume around the implants was not affected by polarization. Thus, using the polarized implant, this study identified that controlled surface charges have a significant effect on the properties of titanium implants. The application of the electrical polarization process and the polarization‐enhanced osteoinductivity, which resulted in greater bone–implant integration, was clearly demonstrated. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3077–3086, 2014.