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Magnesium metal—A potential biomaterial with antibone cancer properties
Author(s) -
Nan Ma,
Yangmei Chen,
Bangcheng Yang
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34933
Subject(s) - radical , biomaterial , materials science , cancer , cancer cell , antioxidant , bone metastasis , reactive oxygen species , bone healing , biophysics , metastasis , magnesium , biomedical engineering , cancer research , chemistry , nanotechnology , biochemistry , medicine , surgery , biology , metallurgy
Reactive oxygen plays an important role in the pathogenesis of many serious illnesses, including bony cancer. Recently, it has been suggested that hydrogen (H 2 ), a selective antioxidant, can effectively scavenge free radicals. Biomedical magnesium (Mg) used for bone defect repair in the surgery of bony cancer could release H 2 because of the degradation, so Mg might have the potential to prevent bony cancer from metastasis and recurrence. In this study, alkali‐heat treatment method was employed to modify the surface structure of Mg metal, so as to control the degradation of Mg metal and the H 2 releasing rate. Then the released H 2 was introduced to the Fenton Reaction system to detect its effect on scavenging free radicals. The modified Mg metal was employed as the substrate for bone cancer cell culture to study the effect of the H 2 releasing on scavenging free radicals in the cells. It is found that the H 2 released from the Mg degradation could scavenge free radicals both in the Fenton Reaction system and bone cancer cells. The effect on the scavenging free radical is proportional to the rate of H 2 releasing. It suggested that Mg might be a potential material with anti‐bone cancer properties. It is hopeful to both repair the bone defect and prevent bony cancer from metastasis and recurrence for the bony cancer patients by biomedical Mg metal. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2644–2651, 2014.