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Photoinitiated chemical vapor deposition of cytocompatible poly(2‐hydroxyethyl methacrylate) films
Author(s) -
McMahon Brian J.,
Pfluger Courtney A.,
Sun Bing,
Ziemer Katherine S.,
Burkey Daniel D.,
Carrier Rebecca L.
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34870
Subject(s) - materials science , methacrylate , chemical engineering , polymer , fourier transform infrared spectroscopy , ethylene glycol , polystyrene , polymerization , chemical vapor deposition , polymer chemistry , conformal coating , 2 hydroxyethyl methacrylate , (hydroxyethyl)methacrylate , thin film , plasma polymerization , x ray photoelectron spectroscopy , coating , composite material , nanotechnology , engineering
Poly(2‐hydroxyethyl methacrylate) (pHEMA) is a widely utilized biomaterial due to lack of toxicity and suitable mechanical properties; conformal thin pHEMA films produced via chemical vapor deposition (CVD) would thus have broad biomedical applications. Thin films of pHEMA were deposited using photoinitiated CVD (piCVD). Incorporation of ethylene glycol diacrylate (EGDA) into the pHEMA polymer film as a crosslinker, confirmed via Fourier transform infrared spectroscopy and X‐ray photoelectron spectroscopy, resulted in varied swelling and degradation behavior. 2‐Hydroxyethyl methacrylate‐only films showed significant thickness loss (up to 40%), possibly due to extraction of low‐molecular‐weight species or erosion, after 24 h in aqueous solution, whereas films crosslinked with EGDA (9.25–12.4%) were stable for up to 21 days. These results differ significantly from those obtained with plasma‐polymerized pHEMA, which degraded steadily over a 21‐day period, even with crosslinking. This suggests that the piCVD films differ structurally from those fabricated via plasma polymerization (plasma‐enhanced CVD). piCVD pHEMA coatings proved to be good cell culture materials, with Caco‐2 cell attachment and viability comparable to results obtained on tissue‐culture polystyrene. Thus, thin film CVD pHEMA offers the advantage of enabling conformal coating of a cell culture substrate with tunable properties depending on method of preparation and incorporation of crosslinking agents. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2375–2382, 2014.