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Biomimetic composites by surface‐initiated polymerization of cyclic lactones at anorganic bone: Preparation and in vitro evaluation of osteoblast and osteoclast competence
Author(s) -
Wiegand Troy,
Hiebner Kris,
Gauza Lukasz,
Schwartz Chris,
Song Zheng,
Miller Steve,
Zacharias Nora,
Wooley Paul H.,
Redepenning Jody
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34840
Subject(s) - materials science , osteoblast , crystallinity , polymerization , osteoclast , composite material , monomer , biomedical engineering , dentistry , in vitro , polymer , chemistry , medicine , biochemistry
Biomimetic composites were constructed using anorganic bone to initiate the polymerization of cyclic lactones. The resulting anorganic bone/polylactone composites preserve the inorganic structure and the mechanical properties of the original bone. Thermal conditions used to prepare the anorganic bone were shown to control the surface functionalities, surface area, and crystallinity, all of which influence the rates of subsequent polymerizations. Thermal pretreatment of anorganic bone was examined as a function of time and temperature, ranging from 400°C to 800°C. Polymerization rates of different monomers were also compared. Additionally, in vitro evaluations of anorganic bone/poly‐ l ‐lactide and anorganic bone/polyglycolide composites for osteoblast and osteoclast competence suggest that these composites are good candidates for potential in vivo use, since both composites promoted osteoblast differentiation. The anorganic bone/poly‐ l ‐lactide composite also promoted osteoclast differentiation. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1755–1766, 2014.