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In vitro biocompatibility of Ti‐45S5 bioglass nanocomposites and their scaffolds
Author(s) -
Kaczmarek M.,
Jurczyk M. U.,
Rubis B.,
Banaszak A.,
Kolecka A.,
Paszel A.,
Jurczyk K.,
Murias M.,
Sikora J.,
Jurczyk M.
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34808
Subject(s) - materials science , nanocomposite , biocompatibility , microcrystalline , bioactive glass , titanium , amorphous solid , crystallization , sintering , chemical engineering , composite material , metallurgy , organic chemistry , engineering , biology , paleontology , chemistry
Titanium–10 wt % 45S5 Bioglass nanocomposites and their scaffolds were prepared by mechanical alloying (MA) followed by pressing, sintering, or combination of MA and a “space‐holder” sintering process, respectively. An amorphous structure was obtained at 15 h of milling. The crystallization of the amorphous phase upon annealing led to the formation of a nanostructured Ti–10 wt % 45S5 Bioglass composite with a grain size of approximately 7 nm. The in vitro cytocompatibility of these materials was evaluated and compared with a conventional microcrystalline titanium. During the studies, established cell line of human fibroblasts CCD‐39Lu was cultured in the presence of tested materials and its survival rate, and proliferation activity were examined. Furthermore, the influence of the Ti–45S5 Bioglass nanocomposites and microcrystalline titanium was tested on the growth of Candida albicans yeast. Biocompatibility tests carried out indicate that the nanocomposite Ti–10 wt % 45S5 Bioglass scaffolds could be a possible candidate for dental implants and other medicinal applications. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1316–1324, 2014.