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Rheological studies of polysaccharides for skin scaffolds
Author(s) -
Almeida Nalinda,
Mueller Anja,
Hirschi Stanley,
Rakesh Leela
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34805
Subject(s) - self healing hydrogels , carrageenan , xanthan gum , materials science , rheology , polysaccharide , biocompatibility , chemical engineering , dynamic mechanical analysis , natural gum , composite material , polymer , polymer chemistry , organic chemistry , chemistry , food science , engineering , metallurgy
Polysaccharide hydrogels are good candidates for skin scaffolds because of their inherent biocompatibility and water transport properties. In the current study, hydrogels were made from a mixture of four polysaccharides: xanthan gum, konjac gum, iota‐carrageenan, and kappa‐carrageenan. Gel formation, strength, and structure of these polysaccharides were studied using rheological and thermal techniques. All gel samples studied were strong gels at all times because of the gradual water loss. However, after 12 h of storage, elastic ( G ') and loss ( G '') moduli of hydrogel mixture containing all the ingredients is of one to two orders of magnitude greater than that of mixtures not containing either xanthan gum or iota‐carrageenan, which confirmed the varied levels of gel strength. This is mainly due to the rate of water loss in each of these mixtures, resulting in gels of varying structures and dynamic moduli over a period of time. Iota‐carrageenan and xanthan gum differ in their effect on gel strength and stability in combination with konjac gum and kappa‐carrageenan. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1510–1517, 2014.