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Effect of concentration and molecular weight of chitosan and its derivative on the free radical scavenging ability
Author(s) -
Li Huili,
Xu Qing,
Chen Yun,
Wan Ajun
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34749
Subject(s) - chitosan , scavenging , antioxidant , materials science , chemiluminescence , derivative (finance) , hydroxyl radical , chemical engineering , nuclear chemistry , organic chemistry , chemistry , financial economics , engineering , economics
Chitosan is a biodegradable and biocompatible natural scaffold material, which has numerous applications in biomedical sciences. In this study, the in vitro antioxidant activity of chitosan scaffold material was investigated by the chemiluminescence signal generated from the hydroxyl radical (•OH) scavenging assay. The scavenging mechanism was also discussed. The results indicated that the free radical scavenging ability of chitosan scaffold material significantly depends on the chitosan concentration and shows interesting kinetic change. Within the experimental concentration range, the optimal concentration of chitosan was 0.2 mg/mL. The molecular weight of chitosan also attributed to the free radical scavenging ability. Comparison between chitosan and its derivative found that carboxymethyl chitosan possessed higher scavenging ability. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 911–916, 2014.