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Alternating block polyurethanes based on PCL and PEG as potential nerve regeneration materials
Author(s) -
Li Guangyao,
Li Dandan,
Niu Yuqing,
He Tao,
Chen Kevin C.,
Xu Kaitian
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34732
Subject(s) - materials science , polyurethane , peg ratio , contact angle , scanning electron microscope , ethylene glycol , diol , elastomer , fourier transform infrared spectroscopy , hexamethylene diisocyanate , polyester , chemical engineering , adhesion , polymer chemistry , composite material , finance , engineering , economics
Polyurethanes with regular and controlled block arrangement, i.e., alternating block polyurethanes (abbreviated as PUCL‐ alt ‐PEG) based on poly(ε‐caprolactone) (PCL‐diol) and poly(ethylene glycol) (PEG) was prepared via selectively coupling reaction between PCL‐diol and diisocyanate end‐capped PEG. Chemical structure, molecular weight, distribution, and thermal properties were systematically characterized by FTIR, 1 H NMR, GPC, DSC, and TGA. Hydrophilicity was studied by static contact angle of H 2 O and CH 2 I 2 . Film surface was observed by scanning electron microscope (SEM) and atomic force microscopy, and mechanical properties were assessed by universal test machine. Results show that alternating block polyurethanes give higher crystal degree, higher mechanical properties, and more hydrophilic and rougher (deep ravine) surface than their random counterpart, due to regular and controlled structure. Platelet adhesion illustrated that PUCL‐ alt ‐PEG has better hemocompatibility and the hemacompatibility was affected significantly by PEG content. Excellent hemocompatibility was obtained with high PEG content. CCK‐8 assay and SEM observation revealed much better cell compatibility of fibroblast L929 and rat glial cells on the alternating block polyurethanes than that on random counterpart. Alternating block polyurethane PUC20‐ a ‐E4 with optimized composition, mechanical, surface properties, hemacompatibility, and highest cell growth and proliferation was achieved for potential use in nerve regeneration. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 685–697, 2014.