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Development of a guided bone regeneration device using salicylic acid‐poly(anhydride‐ester) polymers and osteoconductive scaffolds
Author(s) -
Mitchell Ashley,
Kim Brian,
Cottrell Jessica,
Snyder Sabrina,
Witek Lukasz,
Ricci John,
Uhrich Kathryn E.,
Patrick O'Connor J.
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34728
Subject(s) - materials science , biomedical engineering , craniofacial , regeneration (biology) , bone healing , soft tissue , bone tissue , craniofacial surgery , scaffold , anatomy , surgery , medicine , microbiology and biotechnology , biology , psychiatry
Abstract Successful repair of craniofacial and periodontal tissue defects ideally involves a combined therapy that includes inflammation modulation, control of soft tissue infiltration, and bone regeneration. In this study, an anti‐inflammatory polymer, salicylic acid‐based poly(anhydride‐ester) (SAPAE) and a three‐dimensional osteoconductive ceramic scaffold were evaluated as a combined guided bone regeneration (GBR) system for concurrent control of inflammation, soft tissue ingrowth, and bone repair in a rabbit cranial defect model. At time periods of 1, 3, and 8 weeks, five groups were compared: (1) scaffolds with a solid ceramic cap (as a GBR structure); (2) scaffolds with no cap; (3) scaffolds with a poly(lactide‐glycolide) cap; (4) scaffolds with a slow release SAPAE polymer cap; and (5) scaffolds with a fast release SAPAE polymer cap. Cellular infiltration and bone formation in these scaffolds were evaluated to assess inflammation and bone repair capacity of the test groups. The SAPAE polymers suppressed inflammation and displayed no deleterious effect on bone formation. Additional work is warranted to optimize the anti‐inflammatory action of the SAPAE, GBR suppression of soft tissue infiltration, and stimulation of bone formation in the scaffolds and create a composite device for successful repair of craniofacial and periodontal tissue defects. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 655–664, 2014.