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In vitro and in vivo degradation behavior of n‐HA/PCL‐Pluronic‐PCL polyurethane composites
Author(s) -
Fu ShaoZhi,
Meng XiaoHang,
Fan Juan,
Yang LingLin,
Lin Sheng,
Wen QingLian,
Wang BiQiong,
Chen LanLan,
Wu JingBo,
Chen Yue
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34717
Subject(s) - materials science , composite material , polyurethane , fourier transform infrared spectroscopy , caprolactone , scanning electron microscope , contact angle , wetting , absorption of water , differential scanning calorimetry , copolymer , biomaterial , polycaprolactone , degradation (telecommunications) , swelling , thermogravimetric analysis , chemical engineering , polymer , telecommunications , physics , computer science , engineering , thermodynamics , nanotechnology
Scaffolds for bone tissue engineering applications should have suitable degradability in favor of new bone ingrowth after implantation into bone defects. In this study, degradation behavior of polyurethane composites composed of triblock copolymer poly(caprolactone)–poluronic–poly(caprolactone) (PCL–Pluronic–PCL, PCFC) and nanohydroxyapatite (n‐HA) was investigated. The water contact angle and water absorption were measured to reveal the effect of n‐HA content on the surface wettability and swelling behavior of the n‐HA/PCFC composites, respectively. The weight loss in three degradation media with pH value of 4.0, 7.4, and 9.18 was also studied accordingly. Fourier transform infrared analysis, differential scanning calorimeter, X‐ray diffraction, thermal‐gravimetric analysis, and scanning electron microscopy were used to investigate the change of chemical structure and micromorphology after the n‐HA/PCFC composite with 30% HA was degraded for different time intervals. Meanwhile, in vivo degradation was conducted by subcutaneous implantation. The weight loss and morphology change during observation periods were also studied. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 479–486, 2014.