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Surface modification of implanted cardiovascular metal stents: From antithrombosis and antirestenosis to endothelialization
Author(s) -
Zhang Kun,
Liu Tao,
Li JingAn,
Chen JunYing,
Wang Jian,
Huang Nan
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34714
Subject(s) - restenosis , surface modification , materials science , stent , bare metal , coating , biomedical engineering , biocompatibility , medicine , nanotechnology , surgery , metallurgy , chemical engineering , engineering
Driven by the complications occurring with bare metal stents and drug‐eluting stents, concerns have been raised over strategies for long‐term safety, with respect to preventing or inhibiting stent thrombosis, restenosis, and in‐stent restenosis in particularly. Surface modification is very important in constructing a buffer layer at the interface of the organic and inorganic materials and in ultimately obtaining long‐term biocompatibility. In this review, we summarize the developments in surface modification of implanted cardiovascular metal stents. This review focuses on the modification of metal stents via coating drugs or biomolecules to enhance antithrombosis, antirestenosis, and/or endothelialization. In addition, we indicate the probable future work involving the modification of the metallic blood‐contacting surfaces of stents and other cardiovascular devices that are under development. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 588–609, 2014.