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Castor oil polymer induces bone formation with high matrix metalloproteinase‐2 expression
Author(s) -
Saran Wallace Rocha,
Chierice Gilberto Orivaldo,
Silva Raquel Assed Bezerra,
Queiroz Alexandra Mussolino,
Paula-Silva Francisco Wanderley Garcia,
Silva Léa Assed Bezerra
Publication year - 2014
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34696
Subject(s) - medullary cavity , materials science , biomedical engineering , bone tissue , bone remodeling , matrix (chemical analysis) , tibia , matrix metalloproteinase , anatomy , medicine , composite material , endocrinology
The aim of this study was to evaluate the modulation of matrix metalloproteinase‐2 (MMP‐2) and −9 (MMP‐9) expression in newly formed bone tissue at the interface between implants derived from castor oil ( Ricinus communis ) polymer and the tibia medullary canal. Forty‐four rabbits were assigned to either Group 1 ( n = 12; control) or Group 2 ( n = 30), which had the tibial medullary canals reamed bilaterally and filled with polymer. CT scans showed no space between the material surface and the bone at the implant/bone marrow interface, and the density of the tissues at this interface was similar to the density measured of other regions of the bone. At 90 days postimplantation, the interface with the polymer presented a thick layer of newly formed bone tissue rich in osteocytes. This tissue exhibited ongoing maturation at 120 and 150 days postimplantation. Overall, bone remodeling process was accompanied by positive modulation of MMP‐2 and low MMP‐9 expression. Differently, in control group, the internal surface close to the medullary canal was lined by osteoblasts, followed by a bone tissue zone with few lacunae filled with osteocytes. Maturation of the tissue of the medullary internal surface occurred in the inner region, with the bone being nonlamellar. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 324–331, 2014.