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Design and development of reactive injectable and settable polymeric biomaterials
Author(s) -
Page Jonathan M.,
Harmata Andrew J.,
Guelcher Scott A.
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34665
Subject(s) - materials science , tissue engineering , regenerative medicine , nanotechnology , biocompatible material , biomedical engineering , engineering , stem cell , biology , genetics
Injectable and settable biomaterials are a growing class of therapeutic technologies within the field of regenerative medicine. These materials offer advantages compared to prefabricated implants because of their ability to be utilized as part of noninvasive surgical procedures, fill complex defect shapes, cure in situ , and incorporate cells and other active biologics. However, there are significant technical barriers to clinical translation of injectable and settable biomaterials, such as achieving clinically relevant handling properties and benign reaction conditions. This review focuses on the engineering challenges associated with the design and development of injectable and chemically settable polymeric biomaterials. Additionally, specific examples of the diverse chemistries utilized to overcome these challenges are covered. The future translation of injectable and settable biomaterials is anticipated to improve patient outcomes for a number of clinical conditions. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3630–3645, 2013.