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New concept for a regenerative and resorbable prosthesis for tendon and ligament: Physicochemical and biological characterization of PLA‐braided biomaterial
Author(s) -
AraqueMonrós María C.,
GamboaMartínez Tatiana C.,
Santos Luis Gil,
Bernabé Sagrario Gironés,
Pradas Manuel Monleón,
Estellés Jorge Más
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34633
Subject(s) - braid , materials science , biomaterial , prosthesis , biomedical engineering , tissue engineering , composite material , nanotechnology , surgery , engineering , medicine
We present a concept for a new regenerative and resorbable prosthesis for tendon and ligament and characterize the physicomechanical and biological behavior of one of its components, a hollow braid made of poly‐lactide acid (PLA) which is the load‐bearing part of the prosthesis concept. The prosthesis consists of a braid, microparticles in its interior serving as cell carriers, and a surface non‐adherent coating, all these parts being made of biodegradable materials. The PLA braid has a nonlinear convex stress–strain behavior with a Young modulus of 1370 ± 90 MPa in the linear, stretched state, and after 12 months of hydrolytic degradation the modulus shows a reduction by a factor of four. Different disinfection methods were tested as to their efficiency in cleansing the braid and preparing it for cell culture. Fibroblasts of L929 line were grown on the PLA braid for 14 days, showing good adherence and proliferation. These studies validate the PLA braid for the intended purpose in the regenerative prosthesis concept. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3228–3237, 2013.