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Biological evaluation of materials for cardiovascular application: The role of the short‐term inflammatory response in endothelial regeneration
Author(s) -
Boccafoschi F.,
Mosca C.,
Ramella M.,
Carmagnola I.,
Chiono V.,
Ciardelli G.,
Cannas M.
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34630
Subject(s) - biocompatibility , materials science , adhesion , plga , regeneration (biology) , cytokine , biomedical engineering , wound healing , macrophage , inflammation , cell adhesion , lactic acid , biophysics , microbiology and biotechnology , nanotechnology , in vitro , immunology , composite material , biology , medicine , biochemistry , nanoparticle , metallurgy , genetics , bacteria
Because of their suitable bio‐mechanical properties, polymeric materials, such as Poly( L ‐lactic acid) (PLLA), and poly (lactic‐co‐glycolic acid) (PLGA), are often used in the biomedical field, in particular for cardiovascular applications. Implanted materials induce several events related to the inflammatory reaction, such as macrophage adhesion and activation with following cytokine release. This work considered the effect of macrophage adhesion and related cytokine release on endothelial cells (PAOEC) proliferation and migration. Slight differences have been shown by the macrophages reaction when in contact with PLLA, PLGA, or PLLA/PLGA blend. However, these differences showed to differently enhance endothelial cells behavior in terms of wound healing. These data suggest the inflammatory reaction as a useful way to consider concerning materials biocompatibility, in order to optimize the endothelial regeneration following vascular prosthetic implants. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3131–3140, 2013.