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Toward mucoadhesive hydrogel formulations for the management of xerostomia: The physicochemical, Biological, and Pharmacological Considerations
Author(s) -
Tsibouklis John,
Middleton Andrew M.,
Patel Nisha,
Pratten Jonathan
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34626
Subject(s) - buccal administration , oral cavity , materials science , context (archaeology) , self healing hydrogels , dental care , biomedical engineering , biochemical engineering , dentistry , medicine , engineering , polymer chemistry , biology , paleontology
Although hydrogel formulations that may be applied to many mucosal surfaces are now readily accessible, little research effort has been concentrated on the development of systems that may be usefully employed for the prolonged hydration of the oral cavity. To this end, and set within the context of oral care in general, this review considers the requirements for the design of hydrogel formulations with an affinity for buccal cells and details methods for evaluating the performance of these formulations as treatments for the management of xerostomia. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3327–3338, 2013.