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Improvement of drug elution in thin mineralized collagen coatings with PLGA‐PEG‐PLGA micelles
Author(s) -
Ling Ting,
Yu Mengfei,
Weng Wenjian,
Wang Huiming,
Cheng Kui,
Lin Jun,
Du Piyi
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34625
Subject(s) - micelle , materials science , coating , plga , drug delivery , biomedical engineering , drug , peg ratio , in vivo , chemical engineering , biophysics , nuclear chemistry , pharmacology , composite material , nanotechnology , nanoparticle , chemistry , organic chemistry , medicine , aqueous solution , finance , engineering , economics , biology , microbiology and biotechnology
A mineralized collagen (MC) coating on metallic implants has shown great potential as orthopedic material due to high biological responses. However, their drug delivery capacity remains unsatisfactory since a serious burst release may occur and long‐term release is hard to be achieved. Aiming to improve the drug‐eluting capability, we incorporated drug‐loaded PLGA‐PEG‐PLGA (PPP) micelles into the thin coating. The in vitro release profiles showed that the burst release in the initial 8 h of the modified coating decreased from 81% to 58% compared to MC coating alone; meanwhile, the release duration was prolonged from 3 days to 1 week. Additionally, the release kinetics of vancomycin hydrochloride (VH, the model drug) could be adjusted by changing the size and concentration of PPP micelles. Interestingly, less initial release of VH caused by micelle immobilization did not affect the antibacterial activity in the early stage of implantation according to the antimicrobial test. The cytocompatibility assay demonstrated that the VH‐loaded PPP micelles did not have negative effect on the bioactivity of coating which greatly enhanced cell activity compared to bare Ti substrates. Thus, the MC coatings with PPP micelles could be an effective implant route for bone repair. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3256–3265, 2013.