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Nanostructured scaffolds for bone tissue engineering
Author(s) -
Li Xiaoming,
Wang Lu,
Fan Yubo,
Feng Qingling,
Cui FuZhai,
Watari Fumio
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34539
Subject(s) - materials science , tissue engineering , nanotechnology , bone tissue , mechanism (biology) , bone formation , scaffold , biomedical engineering , engineering , medicine , philosophy , epistemology , endocrinology
It has been demonstrated that nanostructured materials, compared with conventional materials, may promote greater amounts of specific protein interactions, thereby more efficiently stimulating new bone formation. It has also been indicated that, when features or ingredients of scaffolds are nanoscaled, a variety of interactions can be stimulated at the cellular level. Some of those interactions induce favorable cellular functions while others may leads to toxicity. This review presents the mechanism of interactions between nanoscaled materials and cells and focuses on the current research status of nanostructured scaffolds for bone tissue engineering. Firstly, the main requirements for bone tissue engineering scaffolds were discussed. Then, the mechanism by which nanoscaled materials promote new bone formation was explained, following which the current research status of main types of nanostructured scaffolds for bone tissue engineering was reviewed and discussed. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.