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Functional nanofiber mat of polyvinyl alcohol/gelatin containing nanoparticles of biphasic calcium phosphate for bone regeneration in rat calvaria defects
Author(s) -
Ba Linh Nguyen Thuy,
Lee KapHo,
Lee ByongTaek
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34533
Subject(s) - materials science , polyvinyl alcohol , calvaria , gelatin , nanofiber , osteoblast , nanoparticle , regeneration (biology) , electrospinning , fiber , ultimate tensile strength , adhesion , composite material , chemical engineering , polymer , nanotechnology , in vitro , organic chemistry , chemistry , biochemistry , microbiology and biotechnology , engineering , biology
New biodegradable mats was successfully obtained by functional polyvinyl alcohol (PVA)/Gelatin (GE) blend fiber mats containing different BCP amounts (20, 40, and 50 w/v%) of biphasic calcium phosphate (BCP) nanoparticles for bone regeneration. BCP nanoparticles were loaded and dispersed successfully in the PVA/GE fibrous matrix. The addition of BCP was found to have increased fiber diameter, tensile strength, osteoblast cell adhesion, proliferation, and protein expression. Compared to the others, the 50% BCP‐loaded electrospun PVA/GE fibers had the most favorable mechanical properties, cell attachment and growth, and protein expression. In vivo bone formation was examined using rat models, and increased bone formation was observed for the 50% BCP‐loaded electrospun PVA/GE blends within 2 and 4 weeks. This result suggests that the 50% BCP‐PVA/GE composite nanofiber mat has high potential for use in the field of bone regeneration and tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.