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Degradable magnesium‐based implant materials with anti‐inflammatory activity
Author(s) -
Peng Qiuming,
Li Kun,
Han Zengsheng,
Wang Erde,
Xu Zhigang,
Liu Riping,
Tian Yongjun
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34494
Subject(s) - materials science , biomaterial , magnesium , nitric oxide , extrusion , biomedical engineering , composite material , nanotechnology , metallurgy , organic chemistry , medicine , chemistry
The objective of this study was to prepare a new biodegradable Mg‐based biomaterial, which provides good mechanical integrity in combination with anti‐inflammatory function during the degradation process. The silver element was used, because it improved the mechanical properties as an effective grain refiner and it is also treated as a potential anti‐inflammatory core. The new degradable Mg‐Zn‐Ag biomaterial was prepared by zone solidification technology and extrusion. The mechanical properties were mostly enhanced by fine grain strengthening. In addition, the alloys exhibited good cytocompatibility. The anti‐inflammatory function of degradation products was identified by both interleukin‐1α and nitric oxide modes. The anti‐inflammatory impact was significantly associated with the concentration of silver ion. It was demonstrated that Mg‐Zn‐Ag system was a potential metallic stent with anti‐inflammatory function, which can reduce the long‐term dependence of anti‐inflammatory drug after coronary stent implantation. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.