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Sol–gel‐derived bioactive glass containing SiO 2 –MgO–CaO–P 2 O 5 as an antibacterial scaffold
Author(s) -
Imani Fooladi Abbas Ali,
Hosseini Hamideh Mahmoodzadeh,
Hafezi Forough,
Hosseinnejad Fatemeh,
Nourani Mohammad Reza
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34464
Subject(s) - materials science , escherichia coli , bioactive glass , staphylococcus aureus , nuclear chemistry , biocompatible material , biofilm , antibacterial activity , minimum inhibitory concentration , sol gel , composite number , bacteria , minimum bactericidal concentration , cytotoxicity , bromide , chemical engineering , nanotechnology , biomedical engineering , in vitro , composite material , biochemistry , organic chemistry , chemistry , biology , medicine , genetics , engineering , gene
Bioactive glass (BG) composites with a base of SiO 2 –Na 2 O–CaO–P 2 O 5 are biocompatible biomaterials. The assessment of their abilities for medical applications has interested researchers. We produced a BG‐containing SiO 2 –MgO–CaO–P 2 O 5 by the sol–gel method. To determine the antibacterial effects, we analyzed the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) properties of this product on three microorganisms, Staphylococcus aureus , Escherichia coli and Pseudomonas aeruginosa , known causative agents for biofilm formation on implant surfaces. In addition, we performed the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay to study the cytotoxic effects of our composite on animal cells. Our results demonstrated that our BG product inhibited the growth of bacteria in a concentration‐dependent manner without any cytotoxic effects. Therefore, our BG product can be utilized as an appropriate implant for treating bone and tooth defects. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.