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Synthesis and surface properties of polyurethane end‐capped with hybrid hydrocarbon/fluorocarbon double‐chain phospholipid
Author(s) -
Li Jiehua,
Zhang Yi,
Yang Jian,
Tan Hong,
Li Jianshu,
Fu Qiang
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34431
Subject(s) - materials science , polyurethane , fluorocarbon , differential scanning calorimetry , polypropylene glycol , chemical engineering , polyethylene glycol , polymer , polymer chemistry , fourier transform infrared spectroscopy , composite material , physics , engineering , thermodynamics
Abstract To improve hemocompatibility of biomedical polyurethanes (PUs), a series of new fluorinated phospholipid end‐capped polyurethanes (FPCPUs) as blending PU additives were designed and synthesized using diphenyl methane diisocyanate and 1,4‐butanediol as hard segment, poly(tetramethylene glycol), polypropylene glycol, polycarbonate diols, and polyethylene glycol as soft segments, respectively, aminofunctionalized hybrid hydrocarbon/fluorocarbon double‐chain phospholipid as end‐capper. The bulk structures and surface properties of the obtained FPCPUs were fully characterized by 1 H NMR, Fourier transform infrared, gel permeation chromatography, X‐ray photoelectron spectroscopy, differential scanning calorimetry, atomic force microscopy, and water contact angle measurement. It was found that the phosphatidylcholine groups could enrich on the surfaces and subsurfaces with the help of the fluorocarbon chains and self‐assemble into mimic biomembrane on these polymer surfaces. These surfaces could effectively suppress fibrinogen adsorption, as evaluated by enzyme‐linked immunosorbent assay method. Our work indicates that the FPCPUs should be one of the most potential modified additives for enhancing hemocompatibility of traditional medical PUs. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.