Premium
Therapeutic effect of zinc‐containing calcium phosphate suspension injection in thermal burn‐rats
Author(s) -
Otsuka Makoto,
Shikamura Masayuki,
Otsuka Kuniko,
Sogo Yu,
Ito Atsuo
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34429
Subject(s) - zinc , calcium , saline , materials science , phosphate , nuclear chemistry , sodium , in vitro , zinc phosphate , chemistry , metallurgy , biochemistry , medicine
The aim of this study was to evaluate the efficacy of suspensions of zinc‐containing tricalcium phosphate (TCP) in the healing of thermal burns in rats. β‐ZnTCP containing 10 mol % zinc, α‐ZnTCP containing 0.9 mol % zinc, and ZnSO 4 ·(H 2 O) 7 (ZnSO 4 ) were used. The injections were prepared to suspend ZnSO 4 , α‐ZnTCP, and β‐ZnTCP powders in 2 mL of 1% sodium alginate saline solution containing 2 mg of Zn. In vitro Zn release rates were measured in simulated body fluid. The release of Zn from ZnSO 4 was very fast, but that from α‐ZnTCP and β‐ZnTCP was slowed by transformation to hydroxyapatite. The suspensions were injected into group C (control), D1 (ZnSO 4 ), D2 (α‐ZnTCP), and D3 (β‐ZnTCP) rats after thermal burns treatment for 3 h. The area under the curve for the plasma Zn for group D1 was the highest, and the order was groups D1 > D2 ≥ D3 ≥ C. The wounded area (Aw) of group D1 had almost the same profile as that of group C, and the Aw at 18 days was about 20%. In contrast, the Aw of group D2 and D3 decreased, and on day 15 was 8% and 37%, respectively. The results indicated that the healing process was shorter in the rats given α‐ZnTCP and β‐ZnTCP than those given ZnSO 4 or the control. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.