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Novel selenium‐doped hydroxyapatite coatings for biomedical applications
Author(s) -
RodríguezValencia C.,
LópezÁlvarez M.,
CochónCores B.,
Pereiro I.,
Serra J.,
González P.
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34387
Subject(s) - materials science , selenium , osseointegration , raman spectroscopy , coating , doping , x ray photoelectron spectroscopy , chemical engineering , nuclear chemistry , nanotechnology , metallurgy , implant , chemistry , medicine , physics , surgery , optoelectronics , engineering , optics
Abstract Nowadays there is a short‐term need of investigating in orthopedic implants with a greater functionality, including an improved osseointegration and also antibacterial properties. The coating of metallic implants with hydroxyapatite (HA) remains to be the main proposal, but superior quality HA coatings with compositions closer to natural bone apatites, including carbonates, trace elements are required. Selenium is an essential nutrient in biological tissues and, at the same time, it also presents antibacterial properties. A pioneering study on the fabrication of selenium‐doped carbonated hydroxyapatite ( i HA:Se) coatings by Pulsed Laser Deposition (PLD) is presented. Different proportions of selenium were incorporated to obtain the i HA:Se coatings. Their physicochemical characterization, performed by SEM/EDS, FTIR, FT‐Raman, Interferometric Profilometry and XPS, revealed typical columnar growth of HA in globular aggregates and the efficient incorporation of selenium into the HA coatings by the, most probably, substitution of SeO 3 2−groups in the CO 3 2−sites. Biological evaluation illustrated the absence of cytotoxicity when an amount of 0.6 at.% of Se was added to the i HA:Se coatings and excellent proliferation of the MC3T3‐E1 preosteoblasts. Antibacterial properties were also proved with the inhibition of P. aeruginosa and S. aureus from establishing bacterial biofilms. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 853–861, 2013.