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Polyurethanes containing zwitterionic sulfobetaines and their molecular chain rearrangement in water
Author(s) -
Cao Jun,
Yang Mou,
Lu Aijing,
Zhai Shuying,
Chen Yuanwei,
Luo Xianglin
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34384
Subject(s) - differential scanning calorimetry , materials science , polymer , fourier transform infrared spectroscopy , polyurethane , polymer chemistry , gel permeation chromatography , hexamethylene diisocyanate , nuclear chemistry , chemical engineering , chemistry , physics , engineering , composite material , thermodynamics
Novel polyurethanes with zwitterionic sulfobetaines, termed PUR‐APS, were designed and synthesized by chain‐extension of biodegradable poly(ε‐caprolactone) containing N , N ′‐bis (2‐hydroxyethyl) methylamine ammonium propane sulfonate (PCL‐APS) with hexamethylene diisocyanate (HDI). The bulk properties of polymers were characterized by nuclear magnetic resonance spectrum (NMR), Fourier transform infrared spectroscopy (FTIR), gel permeation chromatograph (GPC), and differential scanning calorimetry (DSC). Results showed that the polymers were successfully synthesized. Water contact angles (WCAs) and X‐ray photoelectron spectroscopy (XPS) revealed that molecular chains of the polymers rearranged after soaking in water. The amount of protein adsorption, determined by bicinchoninic acid (BCA) assay, was less than 300 ng/cm 2 and decreased after hydration. The blood compatibility of the polymers was evaluated by the degree of hemolytic and activated partial thromboplastic time (APTT) and prothrombin time (PT). Results indicated that PUR‐APS polymers had good blood compatibility. Therefore, polyurethanes containing sulfobetaines have a great potential for biomedical application. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 909–918, 2013.