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Dopamine‐assisted immobilization of hydroxyapatite nanoparticles and RGD peptides to improve the osteoconductivity of titanium
Author(s) -
Chien ChihYuan,
Liu TseYing,
Kuo WeiHsuan,
Wang MengJiy,
Tsai WeiBor
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34376
Subject(s) - materials science , dopamine , titanium , adhesion , osseointegration , coating , polymerization , cell adhesion , nanotechnology , surface modification , chemical engineering , biomedical engineering , polymer , composite material , metallurgy , medicine , implant , surgery , engineering , endocrinology
Hydroxyapatite (HAp) coating on orthopedic implants is a common strategy to increase osteointegration. In this work, a facile deposition method based on dopamine polymerization was developed for preparation of HAp‐coated titanium substrates for orthopedic applications. Nanostructured HAp was mixed with an alkaline dopamine solution and then deposited onto titanium to form a dopamine/HAp ad‐layer. The deposition of dopamine/HAp greatly enhanced the adhesion, proliferation, and mineralization of osteoblasts. Furthermore, RGD‐containing peptides were immobilized to dopamine/HAp coated titanium and further enhanced cell adhesion and osteogenic differentiation. In conclusion, this facile dopamine‐assisted surface modification method shows a great potential for orthopedic and dental applications. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 740–747, 2013.