Premium
Encapsulation of contrast imaging agents by polypropyleneimine‐based dendrimers
Author(s) -
Balieu S.,
Cadiou C.,
Martinez A.,
Nuzillard J.M.,
Oudart J.B.,
Maquart F.X.,
Chuburu F.,
Bouquillon S.
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34359
Subject(s) - dendrimer , gadolinium , materials science , chelation , biomedical engineering , nuclear chemistry , polymer chemistry , chemistry , medicine , metallurgy
Polypropyleneimines (PPIs) functionalized by glycerol‐based entities are prepared and characterized by diffusion‐ordered spectroscopy NMR. Showing low cytotoxicity against MRC5 fibroblasts, their encapsulation capacities of gadolinium complexes was evaluated. T 1 measurements were performed to determine the relaxivity of the encapsulated gadopentetate dimeglumine (GdBOPTA) in dendrimers of fourth and fifth generation (GD‐PPI‐4 and GD‐PPI‐5). Comparison of the GdBOPTA relaxivity and the relaxivity of GdBOPTA‐loaded dendrimers showed a slight increase of the gadolinium chelate relaxivity. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 613–621, 2013.