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Facile graft of poly(2‐methacryloyloxyethyl phosphorylcholine) onto Fe 3 O 4 nanoparticles by ATRP: Synthesis, properties, and biocompatibility
Author(s) -
Sun XiaoYan,
Yu ShouShan,
Wan JiaQi,
Chen KeZheng
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34343
Subject(s) - phosphorylcholine , biocompatibility , materials science , atom transfer radical polymerization , nanoparticle , monomer , polymerization , polyol , methacrylate , fourier transform infrared spectroscopy , polymer chemistry , chemical engineering , polymer , nanotechnology , polyurethane , chemistry , composite material , biochemistry , engineering , metallurgy
Magnetite (Fe 3 O 4 ) nanoparticles with the surface hydroxyl groups were achieved by a polyol process. Using 2‐(4‐chlorosulfonylphenyl) ethyltrichlorosilane (CTCS) as initiator, 2‐(methacryloyloxy)ethyl phosphorylcholine (MPC) as monomer, poly(2‐(methacryloyloxy)ethyl phosphorylcholine) (PMPC)‐grafted Fe 3 O 4 nanoparticles (MNP) were successfully prepared via the atom transfer radical polymerization (ATRP) method. The successful grafting of PMPC on the Fe 3 O 4 nanoparticles surface was ascertained from the FTIR analysis. The modified nanoparticles (MNP‐CTCS‐PMPC) showed a good biocompatibility in the cytotoxicity test in vitro . Performance testing of MNP‐CTCS‐PMPC was performed through magnetic resonance analysis (MR), and its r 2 / r 1 value was 24.1. These results indicated that the modified Fe 3 O 4 nanoparticles would be a potential MRI contrast reagent. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.