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Strontium calcium phosphate for the repair of leporine ( Oryctolagus cuniculus ) ulna segmental defect
Author(s) -
Mohan Beena G.,
Shenoy Sachin J.,
Babu Suresh S.,
Varma H. K.,
John Annie
Publication year - 2013
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34324
Subject(s) - strontium , materials science , calcium , ulna , phosphate , anatomy , biology , metallurgy , biochemistry , physics , nuclear physics
Scaffolds to aid in repair, replacement, or regeneration of bony tissues have been developed using a wide spectra of materials. Under clinical conditions, assessment of healing and implant placement is guided radiographically. In this context, strontium's role in osteostimulation and its relevance in radio‐opacity are known. Therefore to aid in assessment and to ensure tissue regeneration, a bone mimetic porous strontium calcium phosphate (SrCaPO 4 ) was synthesized in‐house, which was non‐cytotoxic (ISO 10993 (Part V) and subsequently characterized for its crystallinity, functional groups, and 3D porous topography. Furthermore, to assess the feasibility of the bioactive ceramic scaffolds in bone repair, SrCaPO 4 and hydroxyapatite (HA—Control) scaffolds were implanted in the segmental ulna bone critical‐sized defect (1.5 cm) of New Zealand White Rabbits (leporine model— Oryctolagus cuniculus ) for a period of 4 and 12 weeks, respectively. Healing of the defects was uneventful without any inflammation or infection. Radio‐opacity of SrCaPO 4 within the defect site enabled easy assessment of implant placement and osteointegration. Again, histological evaluation coupled with micro‐CT and histomorphometrical analysis indicated that SrCaPO 4 favored significant de novo bone formation in par with material degradation at 4 and 12 weeks post‐implantation compared to HA at 4 and 12 weeks. Investigations on this radio‐opaque SrCaPO 4 established its role in the repair of critical‐sized segmental defects, proposing it as a suitable bone substitute for clinical reconstructive surgery with easy radiographic evaluation. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A:261–271, 2013.