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In vivo evaluation of novel amine‐terminated nanopore Ti surfaces
Author(s) -
Yu Xiaolin,
Ning Chengyun,
Li Jingping,
Huang Shanshan,
Guo Yuanjun,
Deng Feilong
Publication year - 2012
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34269
Subject(s) - materials science , contact angle , surface roughness , nanopore , osseointegration , nanoporous , scanning electron microscope , porosity , composite material , surface finish , root mean square , biomedical engineering , characterization (materials science) , implant , nanotechnology , medicine , surgery , engineering , electrical engineering
The aim of this study was to evaluate the effects of the novel nanopore Ti surface and amine‐terminated Ti surface on peri‐implant bone formation and bone–implant bonding strength in a rabbit tibiae model. Characterization of the modified Ti surface, such as root‐mean square roughness, contact angle, and surface energy was evaluated using scanning electron microscopy, atomic force microscopy, and a Contact Angle Measurement System, respectively. The results from alkali treatment indicated that an interpenetrating dimensional porosity surface had been formed, whose morphology was similar to the amine‐terminated surface of self‐assembled monolayers after alkali treatment. The micro‐CT demonstrated that the amine‐terminated surface had higher bone volume ratio and higher mean trabecular thickness after 4 weeks of implantation. The push‐out test and histological examination showed no significant differences in the maximal force and bone–implant contact between the terminated surface and alkali‐treated surface. These novel dimensional nanoporous structures can significantly improve the initial stabilization and the osseointegration. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:3428–3435, 2012.