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Myelinated nerve bundles developed on the plano‐concave fibers containing nerve conduit
Author(s) -
Huang WeiChin,
Liao JiunnDer,
Lin ChouChing K.,
Ju MingShaung
Publication year - 2012
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34257
Subject(s) - materials science , axon , bundle , regeneration (biology) , schwann cell , nerve guidance conduit , biomedical engineering , anatomy , composite material , microbiology and biotechnology , biology , medicine
Morphologically and chemically modified plano‐concave fibers (PCFs) are designed as a unit of guided channels for supporting Schwann cells to facilitate mass transport and promote nerve regeneration. The surface‐modified PCFs are imprinted with linearly patterned grooves (LPGs) to guide adherent Schwann cell elongation and axon extension. After being cocultured with PC12 neuron‐like cells, Schwann cells differentiate into the myelinated type and interact with PC12 axons. The myelinated axons aggregate as a linear bundle and extend along the direction of LPGs on a PCF. The cross section of a myelin structure is examined using a transmission electron microscope. The PCFs can potentially bridge gaps in injured nerves, improving the therapeutic efficacy of nerve regeneration. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:3490–3495, 2012.