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In vitro characterizations of mesoporous hydroxyapatite as a controlled release delivery device for VEGF in orthopedic applications
Author(s) -
Poh Chye Khoon,
Ng Suxiu,
Lim Tee Yong,
Tan Hark Chuan,
Loo Joachim,
Wang Wilson
Publication year - 2012
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34252
Subject(s) - materials science , biomedical engineering , osseointegration , implant , transmission electron microscopy , mesoporous material , vascular endothelial growth factor , scanning electron microscope , nanotechnology , vegf receptors , composite material , surgery , medicine , chemistry , cancer research , biochemistry , catalysis
Following bone implant surgery, prolonged ischemic conditions at the implant site often result in postsurgical complications like failure of osseointegration at the bone‐implant interface which can lead to implant failure. Thus, restoration of the vascular supply is paramount to the proper development of the bone. High surface area mesostructured materials have been shown to be attractive candidates for bone regeneration to enhance cell adhesion and cell proliferation. This study uses hydroxyapatite, a naturally occurring mineral in the bone, fabricated to a range of suitable pore sizes, infused with vascular endothelial growth factor (VEGF), to be progressively released to stimulate revascularization. In this study, several characterizations including nitrogen adsorption analysis, Fourier‐transformed infrared spectroscopy, X‐ray diffraction, field emission scanning electron microscope, and transmission electron microscope were used to evaluate the synthesized mesoporous hydroxyapatite (MHA). The results showed that MHA can gradually release VEGF for enhancing revascularization, which is beneficial for orthopedic applications. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:3143–3150, 2012.