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Concurrent improvement in biocompatibility and bioinertness of diamond‐like carbon films with nitrogen doping
Author(s) -
Liao WenHsiang,
Lin ChiiRuey,
Wei DaHua,
Shen YouRuey,
Li YiChieh,
Lee JenAi,
Liang ChiaYao
Publication year - 2012
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34235
Subject(s) - biocompatibility , materials science , diamond like carbon , nanotechnology , biomaterial , doping , biomedical engineering , thin film , optoelectronics , medicine , metallurgy
Abstract The surfaces of implantable biomaterials improving biocompatibility and bioinertness are critical for new application of bioimplantable devices. Diamond‐like carbon (DLC) film is a promising biomaterial with use for coating bioimplantable devices because of its good biocompatibility, bioinertness, and mechanical properties. In this study, concurrent improvement in biocompatibility and bioinertness of DLC films has been achieved using N‐incorporation technique. The N doping degree was found to play an important role in affecting the biocompatibility and bioinertness of N‐doped DLC films. The results indicated that the N‐doped DLC films deposited at N 2 concentration of 5% could help to create suitable condition of surface/structure/adhesion combination of DLC films in the both affinity of the L929 mouse fibroblasts and electrochemical inertness in the Hank's balanced salt solutions (simulating human body fluids). N doping supports the attachment and proliferation of cells and prevents the permeation of electrolyte solutions, thereby simultaneity improved the biocompatibility and bioinertness of DLC films. This finding is useful for the fabrication and encapsulation of in vivo devices without induced immune response in the human body. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:3151–3156, 2012.