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Simvastatin‐loaded macroporous calcium phosphate cement: Preparation, in vitro characterization, and evaluation of in vivo performance
Author(s) -
Yin Han,
Li YongGang,
Si Meng,
Li JianMin
Publication year - 2012
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34228
Subject(s) - biocompatibility , materials science , simvastatin , sodium dodecyl sulfate , calcium , biomedical engineering , in vivo , calcium phosphate cement , phosphate , nuclear chemistry , chemical engineering , chromatography , pharmacology , chemistry , biochemistry , metallurgy , medicine , microbiology and biotechnology , engineering , biology
The aim of our study was to construct macroporous calcium phosphate bone cements (CPCs) with enhanced osteogenic potential. For this purpose, 300 m M sodium dodecyl sulfate (SDS) as an air‐entraining agent was added to the liquid phase and 1, 5, and 10% simvastatin (SIM) was homogenized with the solid phase. The physical and mechanical characteristics of the test samples were investigated. Biological properties of the new CPCs were examined after intramuscular and endosteal implantation in rabbits. The introduction of SDS produced interconnected macropores and did not significantly affect initial setting time, transformation of solid phase to hydroxyapatite, and biocompatibility of CPCs. Large amounts (10 wt %) of SIM could decrease the compressive strength and induce severe muscular necrosis and inflammatory reaction. Small amounts (1 wt %) of SIM were compatible with the CPCs did not affect the physico‐chemical properties or biocompatibility and were sufficient to enhance the osteogenic potential of macroporous CPCs. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:2991–3000, 2012.