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Sustained delivery of paclitaxel using thermogelling poly(PEG/PPG/PCL urethane)s for enhanced toxicity against cancer cells
Author(s) -
Loh Xian Jun,
Yee Benjamin Jia Han,
Chia Fu Siong
Publication year - 2012
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34198
Subject(s) - paclitaxel , materials science , ethylene glycol , copolymer , fourier transform infrared spectroscopy , poloxamer , aqueous solution , polyvinyl alcohol , gel permeation chromatography , hela , ether , polymer , chemical engineering , nuclear chemistry , polymer chemistry , organic chemistry , chemistry , cancer , in vitro , composite material , medicine , biochemistry , engineering
A multiblock poly(ether ester urethane)s comprising poly(ε‐caprolactone), poly(ethylene glycol), and poly(propylene glycol) segments was synthesized. The aqueous copolymer solution exhibited thermogelling behavior at a critical gelation concentration of 3 wt %. The chemical structure and molecular characteristic of the copolymers were studied by gel permeation chromatography, NMR, and fourier transform infrared spectroscopy (FTIR). Rheological characterizations on the thermogel were carried out. Drug release studies using paclitaxel showed that sustained drug release of more than 2 weeks can be achieved with this system. The paclitaxel‐loaded gels showed efficiency in the control of the growth of HeLa cells when compared with the paclitaxel dissolved in solution or paclitaxel encapsulated in Pluronics F127. The results demonstrated that the copolymers could be potentially used in chemotherapeutic applications. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A 100A:2686–2694, 2012.