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Effect of pore architecture and stacking direction on mechanical properties of solid freeform fabrication‐based scaffold for bone tissue engineering
Author(s) -
Lee JungSeob,
Cha Hwang Do,
Shim JinHyung,
Jung Jin Woo,
Kim Jong Young,
Cho DongWoo
Publication year - 2012
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34149
Subject(s) - materials science , scaffold , stacking , fabrication , polycaprolactone , tissue engineering , biomedical engineering , nanotechnology , composite material , chemistry , polymer , medicine , alternative medicine , organic chemistry , pathology
Fabrication of a three‐dimensional (3D) scaffold with increased mechanical strength may be an essential requirement for more advanced bone tissue engineering scaffolds. Various material‐ and chemical‐based approaches have been explored to enhance the mechanical properties of engineered bone tissue scaffolds. In this study, the effects of pore architecture and stacking direction on the mechanical and cell proliferation properties of a scaffold were investigated. The 3D scaffold was prepared using solid freeform fabrication technology with a multihead deposition system. Various types of scaffolds with different pore architectures (lattice, stagger, and triangle types) and stacking directions (horizontal and vertical directions) were fabricated with a blend of polycaprolactone and poly lactic‐co‐glycolic acid. In compression tests, the triangle‐type scaffold was the strongest among the experimental groups. Stacking direction affected the mechanical properties of scaffolds. An in vitro cell counting kit‐8 assay showed no significant differences in optical density depending on the different pore architectures and stacking directions. In conclusion, mechanical properties of scaffolds can be enhanced by controlling pore architecture and stacking direction. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.