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A novel rotating electrochemically anodizing process to fabricate titanium oxide surface nanostructures enhancing the bioactivity of osteoblastic cells
Author(s) -
Chang ChihHung,
Lee HsinChun,
Chen ChiaChun,
Wu YiHau,
Hsu YuanMing,
Chang YinPen,
Yang TaI,
Fang HsuWei
Publication year - 2012
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34117
Subject(s) - anodizing , materials science , nanowire , nanostructure , titanium , nanotechnology , titanium oxide , oxide , chemical engineering , composite material , metallurgy , aluminium , engineering
Titanium oxide (TiO 2 ) surface layers with various surface nanostructures (nanotubes and nanowires) have been developed using an anodizing technique. The pore size and length of TiO 2 nanotubes can be tailored by changing the anodizing time and applied voltage. We developed a novel method to transform the upper part of the formed TiO 2 nanotubes into a nanowire‐like structure by rotating the titanium anode during anodizing process. The transformation of nanotubes contributed to the preferential chemical dissolution of TiO 2 on the areas with intense interface tension stress. Furthermore, we further compared the effect of various TiO 2 surface nanostructures including flat, nanotubes, and nanowires on bioactive applications. The MG‐63 osteoblastic cells cultured on the TiO 2 nanowires exhibited a polygonal shape with extending filopodia and showed highest levels of cell viability and alkaline phosphatase activity (ALP). The TiO 2 nanowire structure formed by our novel method can provide beneficial effects for MG‐63 osteoblastic cells in attachment, proliferation, and secretion of ALP on the TiO 2 surface layer. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.

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