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Layer‐by‐layer assembly of antibacterial coating on interbonded 3D fibrous scaffolds and its cytocompatibility assessment
Author(s) -
Tang Yanwei,
Zhao Yan,
Wang Hongxia,
Gao Yuan,
Liu Xin,
Wang Xungai,
Lin Tong
Publication year - 2012
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34116
Subject(s) - materials science , coating , layer (electronics) , scaffold , biguanide , polymer , tissue engineering , composite material , matrix (chemical analysis) , fiber , biomedical engineering , medicine , metformin , diabetes mellitus , endocrinology
Bonded fibrous matrices have shown great potential in tissue engineering because of their unique 3D structures and pore characteristics. For some applications, bacterial infections must be taken into account, and antibacterial function is highly desired. In this study, an antibacterial polymer, polyhexamethylene biguanide (PHMB), was applied onto the fiber surface of a bonded poly(ε‐caprolactone) (PCL) fibrous matrix with the objective to achieve both strong antibacterial effect and good cell compatibility. The coatings were prepared by using an electrostatic layer‐by‐layer (LbL) assembly technique, which allowed the control of PHMB loading and coating uniformity on the fiber surface. The PHMB coating provided antibacterial activities, but had no toxicity on mammalian cells. This bonded PCL fibrous matrix with electrostatically self‐assembled PHMB may provide a new antiinfective tissue scaffold for various biomedical applications. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.