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Controlled drug delivery through a novel PEG hydrogel encapsulated silica aerogel system
Author(s) -
Giray Seda,
Bal Tuğba,
Kartal Ayse M.,
Kızılel Seda,
Erkey* Can
Publication year - 2012
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.34056
Subject(s) - materials science , aerogel , drug delivery , ketoprofen , peg ratio , chemical engineering , ethylene glycol , composite number , solubility , supercritical carbon dioxide , swelling , supercritical fluid , composite material , nanotechnology , organic chemistry , chromatography , chemistry , finance , engineering , economics
Abstract A novel composite material consisting of a silica aerogel core coated by a poly(ethylene) glycol (PEG) hydrogel was developed. The potential of this novel composite as a drug delivery system was tested with ketoprofen as a model drug due to its solubility in supercritical carbon dioxide. The results indicated that both drug loading capacity and drug release profiles could be tuned by changing hydrophobicity of aerogels, and that drug loading capacity increased with decreased hydrophobicity, while slower release rates were achieved with increased hydrophobicity. Furthermore, higher concentration of PEG diacrylate in the prepolymer solution of the hydrogel coating delayed the release of the drug which can be attributed to the lower permeability at higher PEG diacrylate concentrations. The novel composite developed in this study can be easily implemented to achieve the controlled delivery of various drugs and/or proteins for specific applications. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.