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A theoretical model to characterize the drug release behavior of drug‐eluting stents with durable polymer matrix coating
Author(s) -
Zhao Hugh Q.,
Jayasinghe Dudley,
Hossainy Syed,
Schwartz Lewis B.
Publication year - 2012
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.33246
Subject(s) - materials science , drug , coating , drug delivery , restenosis , biomedical engineering , polymer , diffusion , in vivo , nanotechnology , composite material , stent , pharmacology , surgery , medicine , thermodynamics , physics , microbiology and biotechnology , biology
Abstract The time‐dependent local drug delivery from drug‐eluting stents (DES) plays a critical role in reducing restenosis in intravascular stenting. To better understand the basic mechanism of drug release for certain polymer‐drug‐coated DES platforms, a cylindrical diffusion model was applied successfully to quantitatively describe the experimental drug release data of Dynalink‐E in vitro and in vivo . The results showed that the profiles of Dynalink‐E everolimus release could be controlled by such characteristic parameters as coating thickness and diffusion coefficient. The model could be used to quantitatively characterize the drug release profiles and IVIV correlations. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.