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Antibacterial nanofiber materials activated by light
Author(s) -
Jesenská Soňa,
Plíštil Lukáš,
Kubát Pavel,
Lang Kamil,
Brožová Libuše,
Popelka Štěpán,
Szatmáry Lórant,
Mosinger Jiří
Publication year - 2011
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.33218
Subject(s) - materials science , nanofiber , polystyrene , electrospinning , polycaprolactone , polyurethane , antibacterial activity , polymer , polyamide , oxygen permeability , photosensitizer , irradiation , chemical engineering , polymer chemistry , composite material , oxygen , photochemistry , organic chemistry , chemistry , biology , bacteria , engineering , genetics , physics , nuclear physics
Electrospun polymeric nanofiber materials doped with 5,10,15,20‐tetraphenylporphyrin (TPP) photosensitizer were prepared from four different polymers and were characterized with microscopic methods, steady‐state, and time‐resolved fluorescence and absorption spectroscopy. The polymers used included polyurethane Larithane™ (PUR), polystyrene (PS), polycaprolactone (PCL), and polyamide 6 (PA6). The antibacterial activity of all nanofiber materials against E. coli was activated by visible light and it was dependent on oxygen permeability/diffusion coefficients and the diameter of the polymeric nanofibers. This activity is based on oxidation ability of singlet oxygen O 2 ( 1 Δ g ) that is generated upon irradiation. All tested nanofiber materials exhibited prolonged antibacterial properties, even in the dark after long‐duration irradiation. The post‐irradiation effect was explained by the photogeneration of H 2 O 2 , which provided the material with long‐lasting antibacterial properties. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.