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Osteopontin functionalization of hydroxyapatite nanoparticles in a PDLLA matrix promotes bone formation
Author(s) -
Jensen T.,
Baas J.,
DolathshahiPirouz A.,
Jacobsen T.,
Singh G.,
Nygaard J. V.,
Foss M.,
Bechtold J.,
Bünger C.,
Besenbacher F.,
Søballe K.
Publication year - 2011
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.33166
Subject(s) - materials science , osteopontin , surface modification , composite number , nanoparticle , coating , implant , biomedical engineering , matrix (chemical analysis) , chemical engineering , composite material , nanotechnology , surgery , medicine , engineering
We studied the osteoconductive tissue response of hydroxyapatite (HA) nanoparticles functionalized with osteopontin (OPN) in a matrix of poly‐ D,L ‐lactic‐acid (PDLLA). In a canine endosseus 0.75‐mm gap implant model, we tested the osteointegrative impact of the OPN functionalized composite as an implant coating, and a non‐functionalized composite was used as reference control. During the four weeks of observation, the OPN functionalized composite coating significantly increased the formation of new bone in the porosities of the implant, but no differences were observed in the gap. The study provides evidence of its potential use either alone or in combination with other osteoconductive compounds. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 99A: 94–101, 2011.