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BV‐2 microglial cells sense micro‐nanotextured silicon surface topology
Author(s) -
Persheyev Saydulla,
Fan Yongchang,
Irving Andrew,
Rose Mervyn J.
Publication year - 2011
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.33159
Subject(s) - materials science , nanotechnology , substrate (aquarium) , adhesion , silicon , excimer laser , nanostructure , amorphous silicon , surface modification , amorphous solid , biomaterial , laser , topology (electrical circuits) , optoelectronics , crystalline silicon , optics , composite material , chemical engineering , crystallography , oceanography , physics , chemistry , engineering , mathematics , combinatorics , geology
Artificial biomimetic substrates provide useful models for studying cell adhesion, signaling, and differentiation. This article describes biological interactions with a new type of tunable, micro‐nanotextured silicon substrate, generated by irradiation of a hydrogenated amorphous silicon film with a large beam, excimer laser (248 nm). In this study, we demonstrate that BV‐2 microglial cells can sense differences in laser processed silicon surface topology over the range of 30 nm to 2 μm, where they undergo marked morphogenic changes with increasing feature size. The cells adopt a more elongated shape in the presence of the modified surface structure and exhibit increased levels of actin‐rich microdomains, suggesting enhanced adhesion. The excimer laser modification of hydrogenated amorphous silicon to generate micro‐nanostructures realizes large area benefits as well as providing a biomaterial where the external and internal structure can be altered and tuned for various applications. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 99A: 135–140, 2011.

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