Premium
In vivo comparative biokinetics and biocompatibility of titanium and zirconium microparticles
Author(s) -
Olmedo Daniel G.,
Tasat Deborah R.,
Evelson Pablo,
Rebagliatti Raúl,
Guglielmotti María B.,
Cabrini Rómulo L.
Publication year - 2011
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.33145
Subject(s) - biocompatibility , materials science , zirconium , zirconium dioxide , titanium , titanium dioxide , corrosion , in vivo , nuclear chemistry , antioxidant , metallurgy , chemical engineering , biomedical engineering , biochemistry , medicine , chemistry , microbiology and biotechnology , engineering , biology
Titanium and zirconium are biomaterials that present a layer of titanium dioxide (TiO 2 ) or zirconium dioxide (ZrO 2 ). As a result of corrosion, microparticles can be released into the bioenvironment, and their effect on tissues is seemingly associated with differences in the physicochemical properties of these metals. The aim of this study was to perform a long‐term evaluation of the distribution, destination, and potential risk of TiO 2 and ZrO 2 microparticles that might result from the corrosion process. Wistar rats were i.p. injected with an equal dose of either TiO 2 or ZrO 2 suspension. The following end‐points were evaluated at 3, 6, and 18 months: (a) the presence of particles in blood cells and liver and lung tissue, (b) Ti and Zr deposit quantitation, (c) oxidant–antioxidant balance in tissues, and (d) O 2 − generation in alveolar macrophages. Ti and Zr particles were detected in blood mononuclear cells and in organ parenchyma. At equal doses and times postadministration, Ti content in organs was consistently higher than Zr content. Ti elicited a significant increase in O 2 − generation in the lung compared to Zr. The consumption of antioxidant enzymes was greater in the Ti than in the Zr group. The present study shows that the biokinetics of TiO 2 and ZrO 2 depends on particle size, shape, and/or crystal structure. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.